Stepwise mutation model and distribution of allelic frequencies in a finite population.
نویسندگان
چکیده
منابع مشابه
Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles.
A formula for the distribution of allelic frequencies in a finite population is derived assuming stepwise production of multiple alleles. Monte Carlo experiments were performed to check the validity of the formula, and excellent agreement was obtained between theoretical distribution and experimental results. The formula should be useful for analyzing genetic variability in natural populations ...
متن کاملStatistical properties of population differentiation estimators under stepwise mutation in a finite island model.
Microsatellite loci mutate at an extremely high rate and are generally thought to evolve through a stepwise mutation model. Several differentiation statistics taking into account the particular mutation scheme of the microsatellite have been proposed. The most commonly used is R(ST) which is independent of the mutation rate under a generalized stepwise mutation model. F(ST) and R(ST) are common...
متن کاملAllele frequencies at microsatellite loci: the stepwise mutation model revisited.
We summarize available data on the frequencies of alleles at microsatellite loci in human populations and compare observed distributions of allele frequencies to those generated by a simulation of the stepwise mutation model. We show that observed frequency distributions at 108 loci are consistent with the results of the model under the assumption that mutations cause an increase or decrease in...
متن کاملThe distribution of allelic and genotypic frequencies of N-Acetyltransferase-2 variants in an Argentine population.
INTRODUCTION Arylamine N-acetyltransferase-2 (NAT-2) is a key human enzyme in drug detoxification and elimination. Mutations in NAT-2 affect the activity of anti-tuberculosis drugs and result in three different phenotypes: rapid (RA), intermediate (IA) and slow acetylators (SA). METHODOLOGY The allelic, genotypic and phenotypic frequencies of NAT-2 were studied in 185 patients from Buenos Air...
متن کاملa study of relationship between knowledge sharing and organizational agility among personnel in esfahan power electric distribution company
پژوهش حاضر به بررسی رابطه بین تسهیم دانش و چابکی سازمانی در شرکت توزیع برق استان اصفهان پرداخته است . ابزار سنجش در این پژوهش پرسشنامه می باشد . به منظور سنجش متغیر تسهیم دانش از پرسشنامه وانگ و وانگ و جهت سنجش چابکی سازمانی از پرسشنامه چاربونیر استفاده شده است . هدف پژوهش حاضر تحلیل رابطه میان تسهیم دانش و چابکی سازمانی از دید کارکنان شرکت توزیع برق استان اصفهان می باشد . جامعه آماری این پژوه...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1978
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.75.6.2868